- Allen, Thomas C.Co-completed the first transcontinental flight by Black pilots in U.S. history, serving as mechanic and co-pilot alongside James Herman Banningunknown
- Banning, James HermanFirst African American to be licensed as a pilot by the U.S. government; co-completed the first transcontinental flight by Black pilots1899-1933
- Beard, AndrewImproved automatic railroad car coupler (Janney coupler design)1849-1921
- Bluford, Guion 'Guy' Jr.Aerospace engineering and human spaceflight1942-
- Bolden, Charles Frank Jr.First African American NASA Administrator, appointed by President Obama in 2009; piloted and commanded four Space Shuttle missions, including the mission that deployed the Hubble Space Telescope; personally encouraged to apply as an astronaut by Ronald McNair, already profiled in this collection1946-
- Brown, Willa BeatriceFirst African American woman to earn a commercial pilot's license in the United States; trained roughly 200 future Tuskegee Airmen1906-1992
- Certain, Jerry M.Patented the parcel carrier for bicyclesunknown
- Cherry, Matthew A.Improvements to the velocipede leading to a tricycle design, and a streetcar fender to reduce collision damage and improve safety1834-after 1895
- Coleman, BessieFirst African-American woman to earn a pilot's license1892-1926
- Fields, MaryFirst African American woman to work as a U.S. Postal Service Star Route mail carrierc.1832-1914
- Glover, Victor J.Spacecraft systems engineering; commercial spaceflight operations1976-
- Godfrey, John (mariner)One of the small cohort of Black captains to command integrated crews aboard Liberty ships during World War IIunknown
- Gregory, Frederick DrewFirst African American to pilot a space shuttle and first to command a spaceflight; later became NASA's first Black Deputy Administrator and briefly served as the agency's first Black Acting Administrator; nephew of blood plasma pioneer Charles Drew, already profiled in this collection1941-
- Healy, Michael AugustineFirst person of African descent to command a federal ship in U.S. history, commissioned by President Lincoln in 18651839-1904
- Jemison, Mae CarolFirst African American woman to travel into space1956-
- Johnson, Isaac R.Patented the first folding bicycle frame with a recognizably modern diamond shape, the design pattern still used in 21st-century bicyclesunknown
- Johnson, WesleyFour-wheeled velocipede design for novice cyclistsunknown
- Jones, Frederick McKinleyAutomatic refrigeration systems for trucks and railroad cars1893-1961
- Knox, KittieFirst African American accepted into the League of American Wheelmen; advocated for Black cyclists' inclusion against the organization's own racial exclusion policy1874-1900
- Lawrence, Robert H. Jr.First African American astronaut selected to any national space program1935-1967
- McNair, Ronald (Expanded profile)Laser physics research and spaceflight engineering1950-1986
- Melvin, LelandSpacecraft payload and crew operations engineering1964-
- Montgomery, BenjaminSteam-powered boat propeller for shallow water navigation1819-1877
- Mulzac, Hugh NathanielFirst African American to command a fully integrated U.S. merchant vessel1886-1971
- Patterson, Charles RichardFounded C.R. Patterson & Sons, the only automobile manufacturing company in U.S. history founded and owned by an African American1833-1910
- Pickering, John F.Fan-driven airship design with directional and altitude controlunknown
- Powell, William J. (aviator)Founded the Bessie Coleman Aero Club and organized the first all-Black air show in U.S. history1897-1942
- Richardson, Adrian T.One of the small number of Black captains to command integrated crews aboard Liberty ships during World War II, alongside Hugh Mulzacunknown
- Roberts, Homer B.Founded the first African American-owned car dealership in the United States1885-1952
- Robinson, John CharlesKnown as the 'Father of the Tuskegee Airmen' for planting the idea of an aviation program at Tuskegee Institute; commanded the Imperial Ethiopian Air Force against the 1935-36 Italian invasion1903-1954
- Sanders, MingoSenior enlisted soldier of the 25th Infantry Bicycle Corps, which completed a nearly 2,000-mile bicycle expedition across the American West in 18971858-1939
- Williams, Joseph BanksFirst African American to graduate from the U.S. Merchant Marine Academy1922-1992
- Wilson, Stephanie D.Spacecraft systems engineering; ISS robotics operations1966-